Fegato Bioartificiale

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Wide gene expression profiling of ischemia-reperfusion injury in human liver transplantation

Ischemia-reperfusion injury (IRI) causes up to 10% of early liver failures in humans and can lead to a higher incidence of acute and chronic rejection. So far, very few studies have investigated wide gene expression profiles associated with the IRI process. The discovery of novel…

Rivista: Liver Transpl. 2007 Jan;13(1):99-113. Data: 08-01-2007 Categoria: Fegato Bioartificiale

The marginal donor: a single-center experience in orthotopic liver transplantation

The use of marginal donors has become more common worldwide due to the sharp increase in recipients with a consequent shortage of suitable organs. The definition of “marginal donor” has not been reached by all centers. We herein analyzed our single-center experience over the last…

Rivista: Transplant Proc. 2006 May;38(4):1069-73. Data: 08-05-2006 Categoria: Fegato Bioartificiale

Significantly improved survival time in pigs with complete liver ischemia treated with a novel bioartificial liver

Aim of the study was to evaluate treatment efficacy and safety of a scaled-up version of our porcine hepatocytes based BAL system in pigs with complete liver ischemia (LIS). Thirty-one pigs underwent total devascularization of the liver (LIS) by termino-lateral porta-caval shunts and sutures around…

Rivista: Int J Artif Organs. 1999 Oct;22(10):701-9. Data: 04-10-1999 Categoria: Fegato Bioartificiale

Phase I clinical trial with the AMC-bioartificial liver

Recently a bio-artificial liver (BAL) system has been developed at the Academic Medical Center (AMC) of Amsterdam to bridge patients with acute liver failure (ALF) to orthotopic liver transplantation (OLT). After successful testing of the AMC-BAL in rodents and pigs with ALF, a phase I…

Rivista: Int J Artif Organs. 2002 Oct;25(10):950-9. Data: 07-10-2002 Categoria: Fegato Bioartificiale

No evidence of in vitro and in vivo porcine endogenous retrovirus infection after plasmapheresis through the AMC-bioartificial liver

BACKGROUND: Currently a number of bioartificial livers (BAL) based on porcine liver cells have been developed as a treatment to bridge acute liver failure patients to orthotopic liver transplantation or liver regeneration. These xenotransplantation related treatments hold the risk of infection of treated patients by…

Rivista: Xenotransplantation. 2005 Jul;12(4):286-92. Data: 04-07-2005 Categoria: Fegato Bioartificiale

Long-term absence of porcine endogenous retrovirus infection in chronically immunosuppressed patients after treatment with the porcine cell-based Academic Medical Center bioartificial liver

BACKGROUND: Clinical use of porcine cell-based bioartificial liver (BAL) support in acute liver failure as bridging therapy for liver transplantation exposes the patient to the risk of transmission of porcine endogenous retroviruses (PERVs) to human. This risk may be enhanced when patients receive liver transplant…

Rivista: Xenotransplantation. 2010 Nov-Dec;17(6):431-9. doi: 10.1111/j.1399-3089.2010.00617.x. Data: 01-11-2010 Categoria: Fegato Bioartificiale

Role of immunosuppression in recurrence after liver transplantation for diethylnitrosamine-induced tumors in rats

Hepatocellular carcinoma is one of the world’s most common malignant diseases, with an increasing incidence related to liver cirrhosis. The purpose of the study was to evaluate the role of immunosuppression in recurrence in rats transplanted after liver tumor induction by diethylnitrosamine (DENA), which has…

Rivista: Transpl Int. 1994;7 Suppl 1:S204-7. Data: 03-01-1994 Categoria: Fegato Bioartificiale

Functional and morphological comparison of three primary liver cell types cultured in the AMC bioartificial liver.

The selection of a cell type for bioartificial liver (BAL) systems for the treatment of patients with acute liver failure is in part determined by issues concerning patient safety and cell availability. Consequently, mature porcine hepatocytes (MPHs) have been widely applied in BAL systems. The…

Rivista: Liver Transpl. 2007 Apr;13(4):589-98. Data: 02-04-2007 Categoria: Fegato Bioartificiale

Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs.

Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide (CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary…

Rivista: FASEB J. 2004 Jul;18(10):1093-5. Epub 2004 May 7. Data: 05-07-2004 Categoria: Fegato Bioartificiale

Bridging a patient with acute liver failure to liver transplantation by the AMC-bioartificial liver.

Recently a phase I clinical trial has been started in Italy to bridge patients with acute liver failure (ALF) to orthotopic liver transplantation (OLT) by the AMC-bioartificial liver (AMC-BAL). The AMC-BAL is charged with 10 x 10(9) viable primary porcine hepatocytes isolated from a specified…

Rivista: Cell Transplant. 2003;12(6):563-8. Data: 06-01-2003 Categoria: Fegato Bioartificiale
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